[paulfoel]

I've had depression for about 12 years but most of this time it was caused by work stress etc. No anxiety really just depression.

Took Prozac for a bit, then PAxil for years but it didnt help completely. Changed to Remeron last summer and it seemed to work OK for a bit but not great.

Changed to effexor in Feb evenatually going up to 225Mg. Co-inciding with this I started getting anxiety, and general insecure feelings about my relationship, and jealousy. Co-incidence? Who knows?

Anyway, recently changed to Cymbalta and although I was OK for a while, things are pretty much the same.

OK. Effexor and Cymbalta boost nonephedrine as well as serotonin (which is all the paxil does). Is there a chance that this boost is causing my anxiety? What about Remeron? Is this the same - blowing my theory out of the water !!!!!

Of course, this change in my anxiety level could just be a co-incidence....

[PenelopeJones]

Well....

Cymbalta wasn't the wonder drug it was laid out to be, for me. It started out great, I guess tweaking all the right neurons and then it boomaranged on me and I was into a bad depression. I didn't blame it on cymbalta at first because, at first, that med had been so good to me. However, I realized it was the thing that had changed, and that I was way worse than before I began it.

So, yes, I beleive you can experience worse things on meds than before you took them. They don't always work. However because of the nature of our illness it's important to work closely with your support team in making changes.

I can't speak to the other drugs as I have not taken those.

[zoogie]

I think your reasoning holds valid since remeron doesn't act like you would expect, it's a one of a kind med with a very odd side effect profile not connected to what it is supposed to do.